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Danvatirsen - AstraZeneca/Ionis Pharmaceuticals

Drug Profile

Danvatirsen - AstraZeneca/Ionis Pharmaceuticals

Alternative Names: AZD-9150-sodium; AZD9150; Danvatirsen-sodium; IONIS-STAT3-2.5Rx; IONIS-STAT3Rx; ISIS-345794; ISIS-481464; ISIS-STAT3-2.5Rx; ISIS-STAT3Rx; STAT3Rx

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Eli Lilly and Company; Isis Pharmaceuticals
  • Developer Acerta Pharma; AstraZeneca; Flamingo Therapeutics; Ionis Pharmaceuticals; MedImmune; Montefiore Medical Center; National Cancer Institute (USA)
  • Class Antineoplastics; Antisense oligonucleotides
  • Mechanism of Action
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bladder cancer; Colorectal cancer; Head and neck cancer; Malignant ascites; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Phase I/II Liver cancer; Non-Hodgkin's lymphoma
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes
  • No development reported Diffuse large B cell lymphoma

Most Recent Events

  • 01 Oct 2023 Phase-I clinical trials in Acute myeloid leukaemia (In volunteers, Second-line therapy or greater, Combination therapy) in USA (IV) (NCT05986240)
  • 01 Oct 2023 Phase-I clinical trials in Acute myeloid leukaemia (Second-line therapy or greater, In volunteers, Monotherapy) in USA (IV) (NCT05986240)
  • 01 Oct 2023 Phase-I clinical trials in Myelodysplastic syndromes (In volunteers, Second-line therapy or greater, Combination therapy) in USA (IV) (NCT05986240)
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