Danvatirsen - AstraZeneca

Drug Profile

Danvatirsen - AstraZeneca

Alternative Names: AZD9150; IONIS-STAT3-2.5Rx; IONIS-STAT3Rx; ISIS-345794; ISIS-481464; ISIS-STAT3-2.5Rx; ISIS-STAT3Rx; STAT3Rx

Latest Information Update: 29 Jun 2018

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At a glance

  • Originator Eli Lilly; Isis Pharmaceuticals
  • Developer AstraZeneca; Ionis Pharmaceuticals; MedImmune; National Cancer Institute (USA)
  • Class Antineoplastics; Antisense oligonucleotides
  • Mechanism of Action STAT3 transcription factor inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Head and neck cancer; Malignant ascites; Non-small cell lung cancer; Pancreatic cancer; Solid tumours
  • Phase I/II Hepatocellular carcinoma; Non-Hodgkin's lymphoma
  • Phase I Diffuse large B cell lymphoma

Most Recent Events

  • 01 Jun 2018 Phase-I clinical trials in Non-Hodgkin's lymphoma (Combination therapy, Second-line therapy or greater) in USA (IV) (NCT03527147)
  • 17 May 2018 Acerta Pharma in collaboration with AstraZeneca plans the PRISM phase I trial for Non-Hodgkin's Lymphoma in USA , (NCT03527147)
  • 08 Feb 2018 AstraZeneca plans a phase Ib/II trial for Solid tumours and Non-small cell lung cancer (Combination therapy, Second-line therapy or greater, First-line therapy, Late-stage disease, Metastatic disease) in United Kingdom in March 2018 (NCT03421353)
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