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Buntanetap - Annovis Bio

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Drug Profile

Buntanetap - Annovis Bio

Alternative Names: (+)-(3aR)-phenserine; (+)-phenserine; ANVS-401; ANVS-405; ANVS402; Buntanetap tartrate; Posiphen; Posiphen Tartrate

Latest Information Update: 21 Aug 2026

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At a glance

  • Originator National Institute on Aging; National Institutes of Health (USA); Raptor Pharmaceutical Corp
  • Developer Annovis Bio; Cenomed BioSciences; Rockefeller University; University of California at Los Angeles
  • Class Antidementias; Antidotes; Antiparkinsonians; Nootropics; Phenylcarbamates; Small molecules; Vascular disorder therapies
  • Mechanism of Action Alpha-synuclein inhibitors; Amyloid beta-protein precursor inhibitors; Tau protein inhibitors; TDP-43 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease; Parkinson's disease
  • Phase II Lewy body disease; Mild cognitive impairment
  • Phase I Down syndrome
  • No development reported Frontotemporal dementia; Huntington's disease; Poisoning; Stroke; Traumatic brain injuries

Most Recent Events

  • 14 Aug 2026 Annovis plans an open-label extension (OLE) study of buntanetap for Alzheimer’s disease in the US in October 2026 (PO)
  • 07 Jul 2026 Annovis Bio completes enrolment in its phase III trial for Alzheimer's disease (Early-stage disease) in USA (PO) (NCT06709014)
  • 15 May 2026 Annovis Bio announces intention to file new drug application (NDA) with the US FDA in early 2027

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