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Buntanetap - Annovis Bio

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Drug Profile

Buntanetap - Annovis Bio

Alternative Names: (+)-(3aR)-phenserine; (+)-phenserine; ANVS-401; ANVS-405; ANVS402; Buntanetap tartrate; Posiphen; Posiphen Tartrate

Latest Information Update: 26 Nov 2025

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At a glance

  • Originator National Institute on Aging; National Institutes of Health (USA); Raptor Pharmaceutical Corp
  • Developer Annovis Bio; Cenomed BioSciences; Rockefeller University; University of California at Los Angeles
  • Class Antidementias; Antidotes; Antiparkinsonians; Nootropics; Phenylcarbamates; Small molecules; Vascular disorder therapies
  • Mechanism of Action Acetylcholinesterase inhibitors; Alpha-synuclein inhibitors; Amyloid beta-protein precursor inhibitors; Huntingtin protein inhibitors; Tau protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease; Parkinson's disease
  • Phase II Lewy body disease; Mild cognitive impairment
  • Phase I Down syndrome
  • No development reported Frontotemporal dementia; Huntington's disease; Poisoning; Stroke; Traumatic brain injuries

Most Recent Events

  • 18 Nov 2025 US FDA has scheduled a Type C meeting in January 2026 to discuss the Company's pathway for Parkinson's disease dementia
  • 17 Nov 2025 Biomarker data from a phase III trial in Parkinson's disease released by Annovis Bio
  • 09 Oct 2025 Pharmacodynamics data from a phase II/III trial for Alzheimer's disease released by Annovis Bio

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