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R-phenserine - Annovis Bio

Drug Profile

R-phenserine - Annovis Bio

Alternative Names: (+)-(3aR)-phenserine; (+)-phenserine; ANVS-401; ANVS-405; Posiphen

Latest Information Update: 02 Nov 2020

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At a glance

  • Originator National Institute on Aging; National Institutes of Health (USA); Raptor Pharmaceutical Corp
  • Developer Annovis Bio; Cenomed BioSciences; Rockefeller University; University of California at Los Angeles
  • Class Antidementias; Antidotes; Antiparkinsonians; Nootropics; Phenylcarbamates; Small molecules
  • Mechanism of Action Acetylcholinesterase inhibitors; Alpha-synuclein inhibitors; Amyloid beta-protein precursor inhibitors; HD protein inhibitors; Tau protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Mild cognitive impairment; Parkinson's disease
  • Phase I Down syndrome
  • Preclinical Traumatic brain injuries
  • No development reported Huntington's disease; Poisoning

Most Recent Events

  • 29 Oct 2020 Annovis Bio plans phase III trials in Alzheimer's disease
  • 29 Sep 2020 Pharmacodynamics data from preclinical trials in Down syndrome released by Annovis Bio
  • 01 Sep 2020 Annovis Bio plans a dose response study in Parkinson's disease
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