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Topsalysin - Sophiris Bio

Drug Profile

Topsalysin - Sophiris Bio

Alternative Names: PRX-302; PSA-PA 1; PSA-PAH 1

Latest Information Update: 24 Dec 2018

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At a glance

  • Originator Johns Hopkins University; University of Victoria
  • Developer Sophiris Bio
  • Class Antineoplastics; Bacterial toxins; Pore forming cytotoxic proteins; Urologics
  • Mechanism of Action Apoptosis stimulants; Cell membrane modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Benign prostatic hyperplasia
  • Phase II Prostate cancer

Most Recent Events

  • 17 Dec 2018 Updated efficacy and adverse events data from a phase IIb trial in Prostate cancer released by Sophiris Bio
  • 14 Nov 2018 Updated efficacy data from a phase IIb trial in prostate cancer released by Sophiris
  • 25 Jun 2018 Interim safety and efficacy data from a phase IIb trial in Prostate cancer released by Sophiris Bio
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