Drug Profile


Alternative Names: Clearazide™; Ledaga; Mechlorethamine gel; Nitrogen mustard topical gel; Topical nitrogen mustard; Valchlor

Latest Information Update: 28 Mar 2018

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At a glance

  • Originator Yaupon Therapeutics
  • Developer Actelion Pharmaceuticals
  • Class Antineoplastics; Nitrogen mustard compounds; Small molecules
  • Mechanism of Action Alkylating agents; T-cell receptor gene inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed Mycosis fungoides

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 21 Mar 2018 Helsinn entered into a licensing agreement to acquire worldwide rights to chlormethine from Actelion for Mycosis fungoides
  • 29 Jan 2018 Actelion and Sidney Kimmel Cancer Center withdraws a phase II trial in Mycosis fungoides prior to enrolment in USA, as the funding was discontinued (NCT03288818)
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