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Chlormethine - Helsinn

Drug Profile

Chlormethine - Helsinn

Alternative Names: Clearazide™; Ledaga; Mechlorethamine gel; Nitrogen mustard topical gel; Topical nitrogen mustard; Valchlor

Latest Information Update: 26 Dec 2018

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At a glance

  • Originator Yaupon Therapeutics
  • Developer Actelion Pharmaceuticals
  • Class Antineoplastics; Nitrogen mustard compounds; Small molecules
  • Mechanism of Action Alkylating agents; T-cell receptor gene inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T-cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed Mycosis fungoides

Most Recent Events

  • 20 Dec 2018 Orphan Europe in-licenses chlormethine from Helsinn to market worldwide (excluding in USA, China, Hong Kong and Israel)
  • 06 Nov 2018 Chlormethine gel is available through a Autorisation Temporaire d’Utilisation (ATU) de cohort for the treatment of Mycosis fungoides in France
  • 24 Jun 2018 Biomarkers information updated
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