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Chlormethine - Actelion Pharmaceuticals/Helsinn

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Drug Profile

Chlormethine - Actelion Pharmaceuticals/Helsinn

Alternative Names: Clearazide™; Ledaga; LEDAGATM; Mechlorethamine gel; Nitrogen mustard topical gel; Topical nitrogen mustard; Valchlor

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Yaupon Therapeutics
  • Developer Actelion Pharmaceuticals; Helsinn; Orphan Europe; Recordati Rare Diseases
  • Class Antineoplastics; Nitrogen mustard compounds; Small molecules
  • Mechanism of Action Alkylating agents; T-cell receptor gene inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mycosis fungoides; Cutaneous T-cell lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Marketed Mycosis fungoides

Most Recent Events

  • 18 Oct 2022 Pharmacodynamics data from a preclinical in vitro study in Mycosis fungoides released by Helsinn
  • 21 Sep 2022 Launched for Mycosis fungoides (Second-line therapy or greater, In adults) in Canada (Topical) before September 2022
  • 01 Sep 2022 Juniper Biologics acquired distribution and supply license of Chlormethine from Helsinn in Australia, Afghanistan, Armenia, Azerbaijan, Bangladesh, Bhutan, Brunei, Cambodia, Georgia, India, Indonesia, Iraq, Kazakhstan, Kyrgyzstan, Laos, Malaysia, Mongolia, Myanmar, Nepal, Pakistan, Philippines, Singapore, South Korea, Sri Lanka, Taiwan, Thailand, Tajikistan, Turkmenistan, Uzbekistan and Vietnam.

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