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Ingenol mebutate - LEO Pharma

Drug Profile

Ingenol mebutate - LEO Pharma

Alternative Names: 3-Ingenyl angelate; I3A; Ingenol-3-angelate; PEP-005; PEP005-015; Picato

Latest Information Update: 29 Apr 2020

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At a glance

  • Originator National Cancer Institute (USA)
  • Developer LEO Pharma; Peplin
  • Class Antineoplastics; Ingenols; Macrocyclic compounds; Small molecules
  • Mechanism of Action Apoptosis stimulants; Immunostimulants; Protein kinase C stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Actinic keratosis
  • No development reported Basal cell cancer; Bladder cancer; Leukaemia; Squamous cell cancer; Warts

Most Recent Events

  • 11 Feb 2020 Discontinued - Registered for Actinic keratosis in European Union (Topical)
  • 11 Feb 2020 Withdrawn for Actinic keratosis in Iceland (Topical)
  • 11 Feb 2020 The European Commission withdrew the marketing authorisation of ingenol mebutate (Picato®) gel for the treatment of actinic keratosis
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