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NE 3107

Drug Profile

NE 3107

Alternative Names: 17α-ethynyl-5-androstene-3β,7β,17β-triol; HE 3286; NE3107; Triolex

Latest Information Update: 02 Aug 2019

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At a glance

  • Originator Hollis-Eden Pharmaceuticals
  • Developer Harbor Therapeutics; National Institutes of Health (USA); NeurMedix
  • Class Anti-inflammatories; Antiepileptic drugs; Antihyperglycaemics; Antiparkinsonians; Hormones; Obesity therapies; Small molecules
  • Mechanism of Action Mitogen activated protein kinase 3 inhibitors; Mitogen-activated protein kinase 1 inhibitors; NF-kappa B inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Cystic fibrosis

Highest Development Phases

  • Phase I Alzheimer's disease; Cognition disorders; Migraine; Myositis; Parkinson's disease
  • Preclinical Amyotrophic lateral sclerosis; Drug-induced dyskinesia; Huntington's disease
  • Discontinued Cystic fibrosis; Epilepsy; Glaucoma; Optic neuritis; Rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Ulcerative colitis; Uveitis

Most Recent Events

  • 02 Aug 2019 Discontinued - Preclinical for Glaucoma in USA (PO) (NeurMedix pipeline, July 2019)
  • 02 Aug 2019 Discontinued - Preclinical for Optic neuritis in USA (PO) (NeurMedix pipeline, July 2019)
  • 02 Aug 2019 Discontinued - Preclinical for Type 1 diabetes mellitus in USA (PO) (NeurMedix pipeline, July 2019)
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