Drug Profile

Bezisterim - BioVie

Alternative Names: 17α-ethynyl-5-androstene-3β,7β,17β-triol; 3α-ethynyl-androst-5-ene-3β,7β,17β-triol; HE 3286; NE-3107; Triolex^®

Latest Information Update: 30 Jun 2025

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At a glance

Originator Hollis-Eden Pharmaceuticals
Developer BioVie; Harbor Therapeutics; National Institutes of Health (USA); NeurMedix
Class Anti-inflammatories; Antidementias; Antiepileptic drugs; Antifibrotics; Antiglaucomas; Antihyperglycaemics; Antimigraines; Antineoplastics; Antiparkinsonians; Antirheumatics; Antivirals; Hormones; Insulin sensitisers; Nootropics; Obesity therapies; Small molecules
Mechanism of Action Adiponectin stimulants; Interleukin 23 inhibitors; Interleukin 6 inhibitors; Mitogen-activated protein kinase 1 inhibitors; Mitogen-activated protein kinase 3 inhibitors; NF-kappa B inhibitors; Tumour necrosis factor inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes - Cystic fibrosis

Phase III Alzheimer's disease
Phase II Parkinson's disease; Post acute COVID 19 syndrome; Traumatic brain injuries
No development reported Drug-induced dyskinesia; Multiple myeloma; Prostate cancer
Discontinued Amyotrophic lateral sclerosis; Cognition disorders; Cystic fibrosis; Epilepsy; Glaucoma; Huntington's disease; Migraine; Myositis; Optic neuritis; Rheumatoid arthritis; Type 1 diabetes mellitus; Type 2 diabetes mellitus; Ulcerative colitis; Uveitis

24 Jun 2025 Updated efficacy data from a phase II trial in Parkinson's disease released by BioVie
24 Jun 2025 Updated efficacy data from a phase II trial in Post-acute-COVID-19-syndrome released by BioVie
29 Apr 2025 Phase-II clinical trials in Post-acute-COVID-19-syndrome (In adults) in USA (PO) (NCT06847191)

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