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NNZ 2591

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Drug Profile

NNZ 2591

Alternative Names: ACP-2591; Cyclo-L-Glycyl-L-2-Allylproline; NNZ-2591; PMS-001

Latest Information Update: 31 Oct 2025

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At a glance

  • Originator Neuren Pharmaceuticals
  • Developer ACADIA Pharmaceuticals; Neuren Pharmaceuticals
  • Class 2 ring heterocyclic compounds; Alkenes; Antiparkinsonians; Behavioural disorder therapies; Cyclic peptides; Neuroprotectants; Nootropics; Piperazines; Pyrazines; Pyrroles; Small molecules; Vascular disorder therapies
  • Mechanism of Action Cell death inhibitors; Neuropeptide receptor modulators; Symporter modulators; Synaptic transmission modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pitt-Hopkins syndrome; Telomeric 22q13 Monosomy Syndrome; Prader-Willi syndrome; Angelman syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Telomeric 22q13 Monosomy Syndrome
  • Phase II Angelman syndrome; Pitt-Hopkins syndrome; Prader-Willi syndrome
  • Phase I Fragile X syndrome; Rett syndrome
  • Preclinical Brain hypoxia-ischaemia

Most Recent Events

  • 20 Oct 2025 Phase-III clinical trials in Telomeric 22q13 Monosomy Syndrome (In children) in USA (PO)
  • 20 Oct 2025 NNZ 2591 receives Fast Track designation for Telomeric 22q13 Monosomy Syndrome [PO] (In children) in USA
  • 10 Oct 2025 Preclinical trials in Brain hypoxia-ischaemia in New Zealand (unspecified route) (Neuren Pharmaceuticals pipeline, October 2025)

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