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NNZ 2591

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Drug Profile

NNZ 2591

Alternative Names: ACP-2591; Cyclo-L-Glycyl-L-2-Allylproline; NNZ-2591

Latest Information Update: 02 Sep 2024

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At a glance

  • Originator Neuren Pharmaceuticals
  • Developer ACADIA Pharmaceuticals; Neuren Pharmaceuticals
  • Class 2 ring heterocyclic compounds; Alkenes; Antiparkinsonians; Behavioural disorder therapies; Cyclic peptides; Neuroprotectants; Nootropics; Piperazines; Pyrazines; Pyrroles; Small molecules; Vascular disorder therapies
  • Mechanism of Action Cell death inhibitors; Neuropeptide receptor modulators; Symporter modulators; Synaptic transmission modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pitt-Hopkins syndrome; Telomeric 22q13 Monosomy Syndrome; Prader-Willi syndrome; Angelman syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Angelman syndrome; Pitt-Hopkins syndrome; Prader-Willi syndrome; Telomeric 22q13 Monosomy Syndrome
  • Phase I Fragile X syndrome; Rett syndrome

Most Recent Events

  • 27 Aug 2024 US FDA granted an end-of-phase II meeting for NNZ 2591 to treat Phelan-McDermid syndrome, scheduled for September 2024
  • 16 Jul 2024 Neuren Pharmaceuticals completes a phase II trial in Angelman Syndrome released by Neuren Pharmaceuticals (NCT05011851)
  • 03 Jun 2024 Neuren Pharmaceuticals suspends phase II trial in Prader-Willi syndrome (In adolescents, In children) in USA (PO), due to forthcoming protocol design updates (NCT05879614)

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