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Fostamatinib - Rigel Pharmaceuticals

Drug Profile

Fostamatinib - Rigel Pharmaceuticals

Alternative Names: FosD; Fostamatinib disodium; Fostamatinib disodium hexahydrate; Fostamatinib sodium; R 985788; R-406/788; R-788; R-935/788; R788 sodium; R935788 sodium; Tamatinib fosdium; Tavalisse

Latest Information Update: 28 Jan 2019

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At a glance

  • Originator Rigel Pharmaceuticals
  • Developer AstraZeneca; Duke University Medical Center; Rigel Pharmaceuticals; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Anti-inflammatories; Antianaemics; Antihyperglycaemics; Antineoplastics; Antirheumatics; Oxazines; Phosphoric acid esters; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Syk kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Autoimmune haemolytic anaemia; Idiopathic thrombocytopenic purpura
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Idiopathic thrombocytopenic purpura
  • Phase II Autoimmune haemolytic anaemia
  • Phase I Graft-versus-host disease; Ovarian cancer
  • Discontinued Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; IgA nephropathy; Rheumatoid arthritis; Solid tumours; Systemic lupus erythematosus; T-cell lymphoma; Type 1 diabetes mellitus

Most Recent Events

  • 23 Jan 2019 Rigel Pharmaceuticals and Grifols enters into collaboration and licence agreement to commercialise fostamatinib in Europe and Turkey
  • 07 Jan 2019 Rigel Pharmaceuticals anticipates a final decision for its MAA for Idiopathic thrombocytopenic purpura in European Union by the end of 2019
  • 06 Jan 2019 Efficacy and safety data from a phase III open-label extension study in Idiopathic thrombocytopenic purpura presented at the 60th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2018)
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