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Nilotinib - Novartis Pharmaceuticals Corporation

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Drug Profile

Nilotinib - Novartis Pharmaceuticals Corporation

Alternative Names: AMN-107; Nilotinib-nanoparticle-formulation-Xspray-Pharma; RightSize-nilotinib; Tasigna

Latest Information Update: 30 Jan 2024

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At a glance

  • Originator Novartis Pharmaceuticals Corporation
  • Developer Centre Hospitalier Univeristaire De Lille; Dana-Farber Cancer Institute; Hospital for Special Surgery; Novartis Pharmaceuticals Corporation; Seoul St. Mary's Hospital; University Health Network of Toronto; University of California, San Diego
  • Class Antineoplastics; Benzamides; Fluorinated hydrocarbons; Imidazoles; Ketones; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action Bcr-Abl tyrosine kinase inhibitors; Platelet-derived growth factor alpha receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto-oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Gastrointestinal stromal tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic myeloid leukaemia
  • Phase II Acral lentiginous melanoma; Gastrointestinal stromal tumours; Glioblastoma; Graft-versus-host disease; Malignant melanoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase I/II Acute myeloid leukaemia
  • No development reported Colorectal cancer; Head and neck cancer; Hypereosinophilic syndrome; Systemic scleroderma
  • Discontinued Eosinophilia

Most Recent Events

  • 09 Dec 2023 Efficacy and adverse event data from a phase II DANTE trial in Chronic myeloid leukaemia presented at the 65th American Society of Hematology Annual Meeting and Exposition (ASH-Hem-2023)
  • 02 Oct 2023 Novartis completes a phase II trial for Gastrointestinal stromal tumours in Japan (PO) (NCT01863745)
  • 28 Sep 2023 No recent reports of development identified for clinical-Phase-Unknown development in Hypereosinophilic-syndrome in Unknown (PO)

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