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Nanatinostat/valganciclovir combination therapy - Viracta Therapeutics

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Drug Profile

Nanatinostat/valganciclovir combination therapy - Viracta Therapeutics

Alternative Names: CHR-3996; Nana-val; Tractinostat; Tractinostat-Viracta-Therapeutics; Valganciclovir/Nanatinostat combination therapy - Viracta Therapeutics; VRx-3996

Latest Information Update: 16 May 2024

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At a glance

  • Originator Chroma Therapeutics
  • Developer Chroma Therapeutics; Viracta Therapeutics
  • Class Amides; Antineoplastics; Antivirals; Hypoxanthines; Pyrimidines; Quinolines; Small molecules
  • Mechanism of Action Cytomegalovirus replication inhibitors; DNA-directed DNA polymerase inhibitors; Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Plasmablastic lymphoma; Peripheral T-cell lymphoma; Diffuse large B cell lymphoma; T-cell lymphoma; Post-transplant lymphoproliferative disorder; Nasopharyngeal cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Lymphoma
  • Phase I/II Multiple myeloma; Nasopharyngeal cancer; Solid tumours
  • Phase I Cancer
  • No development reported Gastric cancer; Post-transplant lymphoproliferative disorder

Most Recent Events

  • 09 May 2024 Japanese PMDA enables patient enrollment for nanatinostat/valganciclovir in phase II NAVAL-1 trial in Japan without previous safety and pharmacokinetics studies
  • 15 Apr 2024 Updated efficacy and adverse events data from the phase II NAVAL-1 trial in Lymphoma released by Viracta Therapeutics
  • 08 Mar 2024 Viracta Therapeutics plans a phase I trial for Cancer (Late-stage disease, Second-line therapy or greater) in Spain (PO, Tablets) (NCT06302140)
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