Cenicriviroc - Tobira Therapeutics

Drug Profile

Cenicriviroc - Tobira Therapeutics

Alternative Names: Cenicriviroc mesylate; CVC; TAK-652; TBR-652

Latest Information Update: 04 Jun 2018

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At a glance

  • Originator National Institute for Health Research; Takeda
  • Developer Allergan; Dong-A ST; Imperial College of Science, Technology and Medicine; National Institute for Health Research; Tobira Therapeutics; University of Hawaii
  • Class Amides; Antifibrotics; Antineoplastics; Antiretrovirals; Imidazoles; Small molecules
  • Mechanism of Action CCR2 receptor antagonists; CCR5 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-alcoholic steatohepatitis
  • Phase II Cognition disorders; HIV-1 infections; Non-alcoholic fatty liver disease; Primary sclerosing cholangitis
  • Phase I Liver disorders
  • Preclinical Cholestasis; Diabetic nephropathies
  • No development reported Cancer; Graft-versus-host disease

Most Recent Events

  • 07 May 2018 Novartis Pharmaceuticals plans the TANDEM phase II trial for Non-alcoholic Steatohepatitis in July 2018 , (NCT03517540)
  • 17 Dec 2017 Allergan completes a phase I trial in Liver disorders in USA (PO) (NCT03376841)
  • 10 Nov 2017 Tobira Therapeutics completes the phase IIb CENTAUR trial for Non-alcoholic steatohepatitis in Australia, Belgium, France, Germany, Hong Kong, Italy, Moldova, Poland, Spain, USA and United Kingdom (PO) (NCT02217475)
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