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Tipelukast - MediciNova

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Drug Profile

Tipelukast - MediciNova

Alternative Names: KCA-757; MN-001

Latest Information Update: 11 Nov 2025

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At a glance

  • Originator Kyorin Pharmaceutical
  • Developer MediciNova
  • Class Anti-inflammatories; Antiasthmatics; Antifibrotics; Hepatoprotectants; Small molecules
  • Mechanism of Action 5-lipoxygenase inhibitors; Leukotriene D4 receptor antagonists; Leukotriene receptor antagonists; Phospholipase C inhibitors; Thromboxane A2 receptor antagonists; Type 3 cyclic nucleotide phosphodiesterase inhibitors; Type 4 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis
  • New Molecular Entity Yes
  • Available For Licensing Yes - Idiopathic pulmonary fibrosis; Non-alcoholic steatohepatitis

Highest Development Phases

  • Phase II Idiopathic pulmonary fibrosis; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis
  • Preclinical Atherosclerosis
  • No development reported Interstitial cystitis
  • Discontinued Asthma

Most Recent Events

  • 04 Nov 2025 MediciNova completes enrolment in its phase II trial in Non-alcoholic fatty liver disease in USA (PO) (NCT05464784)
  • 30 Oct 2025 Preclinical trials in Atherosclerosis in USA (unspecified route) prior to October 2025
  • 30 Oct 2025 Pharmacodynamics data from a preclinical studies in atherosclerosis released by MediciNova

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