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Foretinib

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Drug Profile

Foretinib

Alternative Names: 1363089; EXEL-2880; GSK 089; GSK 1363089; GSK 1363089G; XL 880

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Exelixis
  • Developer GlaxoSmithKline; National Cancer Institute (Canada)
  • Class Anilides; Antineoplastics; Quinolines; Small molecules
  • Mechanism of Action Proto-oncogene protein c-met inhibitors; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Gastric cancer; Head and neck cancer; Liver cancer; Non-small cell lung cancer; Renal cancer

Most Recent Events

  • 01 Mar 2015 GlaxoSmithKline completes a phase I trial for Liver cancer in Hong Kong, Taiwan, and Thailand (NCT00920192)
  • 01 Feb 2015 GlaxoSmithKline completes a phase I/II trial in Non-small cell lung cancer (Second-line therapy or greater, Late-stage disease) in Canada (NCT01068587)
  • 24 Jan 2014 GlaxoSmithKline plans a phase II trial for Non-small cell lung cancer (combination therapy, metastatic disease) in the USA (NCT02034097)

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