Macitentan - Actelion Pharmaceuticals

Drug Profile

Macitentan - Actelion Pharmaceuticals

Alternative Names: ACT-064992; Actelion-1; OPSUMIT; Opsumit; Zependo

Latest Information Update: 04 May 2018

Price : *
* Final gross price and currency may vary according to local VAT and billing address.
* Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase. A link to download a PDF version of the drug profile will be included in your email receipt. Adis is an information provider. We do not sell or distribute the pharmaceutical compounds written about in this database.

At a glance

  • Originator Actelion Pharmaceuticals
  • Developer Actelion Pharmaceuticals; Nippon Shinyaku
  • Class Antifibrotics; Antihypertensives; Antineoplastics; Bromobenzenes; Cardiovascular therapies; Pyrimidines; Skin disorder therapies; Small molecules; Sulfonamides
  • Mechanism of Action Endothelin A receptor antagonists; Endothelin B receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension; Idiopathic pulmonary fibrosis; Pulmonary hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Pulmonary arterial hypertension
  • Preregistration Pulmonary hypertension
  • Phase III Congenital heart defects; Eisenmenger complex
  • Phase II Heart failure
  • Clinical Phase Unknown Portal hypertension
  • Discontinued Glioblastoma; Idiopathic pulmonary fibrosis; Skin ulcer

Most Recent Events

  • 30 Apr 2018 Preregistration for Pulmonary hypertension (chronic thromboembolic pulmonary hypertension) in USA (PO)
  • 04 Apr 2018 Actelion initiates enrolment in the long term safety UMBRELLA trial in Pulmonary arterial hypertension (Treatment experienced, In adults, In the elderly) in France (NCT03422328)
  • 09 Feb 2018 Actelion plans the phase III UMBRELLA trial in Pulmonary arterial hypertension (Treatment experienced, In adults, In the elderly) in France (NCT03422328) (Trial profile 700292884)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top