Brivanib alaninate - ZAI Lab
Alternative Names: BMS-540215; BMS-582664; Brivanib; ZL-2301Latest Information Update: 05 Nov 2023
At a glance
- Originator Bristol-Myers Squibb
- Developer Bristol-Myers Squibb; Gynecologic Oncology Group; Hunan Cancer Hospital; National Cancer Institute (USA); ZAI Lab
- Class Antineoplastics; Esters; Indoles; Pyrroles; Small molecules; Triazines
- Mechanism of Action Angiogenesis inhibitors; Type 1 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Phase II Cervical cancer; Liver cancer
- Phase I/II Cholangiocarcinoma
- No development reported Ovarian cancer; Solid tumours
- Discontinued Colorectal cancer; Gastrointestinal cancer
Most Recent Events
- 08 Jun 2022 ZAI Lab terminates a phase I/II trial in Liver cancer nad Cholangiocarcinoma (In adults, In the elderly, Combination therapy, Second-line therapy or greater, Late-stage disease) in China (IV) due to the rapid shifting of liver cancer disease landscape and the company's adjustment of development strategy (NCT04212221)
- 28 Feb 2022 No recent reports of development identified for phase-I development in Ovarian-cancer(Combination therapy, Second-line therapy or greater) in China (PO)
- 04 Jun 2021 Adverse events data from phase II trial in Cervical cancerwas presented at the 57th Annual Meeting of the American Society of Clinical Oncology (ASCO-2021)