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Brivanib alaninate - ZAI Lab

Drug Profile

Brivanib alaninate - ZAI Lab

Alternative Names: BMS-540215; BMS-582664; Brivanib; ZL-2301

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Gynecologic Oncology Group; Hunan Cancer Hospital; National Cancer Institute (USA); ZAI Lab
  • Class Antineoplastics; Esters; Indoles; Pyrroles; Small molecules; Triazines
  • Mechanism of Action Angiogenesis inhibitors; Type 1 fibroblast growth factor receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cervical cancer; Liver cancer
  • Phase I/II Cholangiocarcinoma
  • No development reported Ovarian cancer; Solid tumours
  • Discontinued Colorectal cancer; Gastrointestinal cancer

Most Recent Events

  • 08 Jun 2022 ZAI Lab terminates a phase I/II trial in Liver cancer nad Cholangiocarcinoma (In adults, In the elderly, Combination therapy, Second-line therapy or greater, Late-stage disease) in China (IV) due to the rapid shifting of liver cancer disease landscape and the company's adjustment of development strategy (NCT04212221)
  • 28 Feb 2022 No recent reports of development identified for phase-I development in Ovarian-cancer(Combination therapy, Second-line therapy or greater) in China (PO)
  • 04 Jun 2021 Adverse events data from phase II trial in Cervical cancerwas presented at the 57th Annual Meeting of the American Society of Clinical Oncology (ASCO-2021)
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