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Camptothecin - BlueLink Pharmaceuticals/Calando Pharmaceuticals

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Drug Profile

Camptothecin - BlueLink Pharmaceuticals/Calando Pharmaceuticals

Alternative Names: Camptothecin-nanoparticle-cerulean; CRLX 101; Cyclosert-CPT; Cyclosert™-enhanced camptothecin; IT-101; NLG 207

Latest Information Update: 29 Dec 2021

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At a glance

  • Originator Insert Therapeutics
  • Developer BlueLink Pharmaceuticals; Cerulean Pharma; Insert Therapeutics; Massachusetts General Hospital; National Cancer Institute (USA); University of North Carolina
  • Class Antineoplastics; Camptothecins; Drug conjugates; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors; Hypoxia-inducible factor-1 alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase II Ovarian cancer; Prostate cancer; Rectal cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase I/II Solid tumours
  • No development reported Breast cancer; Gastric cancer; Non-small cell lung cancer

Most Recent Events

  • 01 Apr 2021 Camptothecin is still in phase-II clinical trials in Prostate cancer (Combination therapy, Metastatic disease, Late-stage disease, Hormone refractory, Second-line therapy or greater) in USA (IV) (NCT03531827)
  • 17 Dec 2019 Camptothecin licensed to Ellipses Pharma worldwide
  • 02 Apr 2019 Updated efficacy and adverse events data from a phase Ib/II trial in Ovarian cancer, Fallopian tube or Peritoneal cancer presented at the American Association for Cancer Research Annual Meeting (AACR-2019)
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