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Bemcentinib - BerGenBio/Rigel Pharmaceuticals

Drug Profile

Bemcentinib - BerGenBio/Rigel Pharmaceuticals

Alternative Names: BGB 324; R-428

Latest Information Update: 06 Dec 2018

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At a glance

  • Originator Rigel Pharmaceuticals
  • Developer BerGenBio; Haukeland University Hospital; Merck Sharp & Dohme; University of Texas Southwestern Medical Center
  • Class Antineoplastics; Benzocycloheptenes; Cycloheptanes; Pyridazines; Pyrrolidines; Small molecules; Triazoles
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Malignant melanoma; Non-small cell lung cancer
  • Phase I/II Myelodysplastic syndromes
  • Phase I Acute myeloid leukaemia
  • Preclinical Idiopathic pulmonary fibrosis; Non-alcoholic steatohepatitis
  • No development reported Chronic myeloid leukaemia; Pancreatic cancer; Solid tumours

Most Recent Events

  • 26 Nov 2018 BerGenBio plans a phase II trials for Acute myeloid leukaemia and Non-small cell lung cancer in 2019
  • 03 Nov 2018 Efficacy and adverse events data from a phase Ib/II trial in Acute myeloid leukaemia and Myelodysplastic syndromes released by BerGenBio
  • 19 Oct 2018 Updated interim efficacy and adverse events data from a phase Ib/II trial in Melanoma at the European Society for Medical Oncology (ESMO-2018)
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