Nivolumab - Bristol-Myers Squibb/Ono Pharmaceuticals

Drug Profile

Nivolumab - Bristol-Myers Squibb/Ono Pharmaceuticals

Alternative Names: BMS-936558; MDX-1106; Nivolumab BMS; ono-0123; ONO-4538; Opdivo

Latest Information Update: 14 Sep 2018

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At a glance

  • Originator Medarex; Ono Pharmaceutical; Sidney Kimmel Cancer Center
  • Developer Aduro BioTech; AIO Studien gGmbH; Australian and New Zealand Urogenital and Prostate Cancer Group; Barbara Ann Karmanos Cancer Institute; Bavarian Nordic; Big Ten Cancer Research Consortium; Bristol-Myers Squibb; Celleron Therapeutics; Clovis Oncology; Curie Institute; Daiichi Sankyo Company; Dana-Farber Cancer Institute; Duke University Medical Center; Eisai Inc; Eli Lilly; Emory University; European Thoracic Oncology Platform; Exelixis; Frontier Science foundation; Grupo Espanol Multidisciplinar de Melanoma; H. Lee Moffitt Cancer Center and Research Institute; Hoosier Cancer Research Network; Incyte Corporation; Intergroupe Francophone de Cancerologie Thoracique; Janssen Biotech; Janssen Research & Development; Kansai Medical University; Kyoto Breast Cancer Research Network; M. D. Anderson Cancer Center; Massachusetts General Hospital; Medarex; Nantes University Hospital; National Cancer Center (Tokyo); National Cancer Centre (Singapore); National Cancer Institute (USA); Nektar Therapeutics; Neon Therapeutics; Netherlands Cancer Institute; Northwestern University; Ono Pharmaceutical; Pharmacyclics; Seattle Genetics; Sidney Kimmel Cancer Center; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Syneos Health; The University of Montreal Hospital Research Center; University College London; University of Liverpool; University of Texas M. D. Anderson Cancer Center; Zucero Therapeutics
  • Class Antineoplastics; Antivirals; Monoclonal antibodies
  • Mechanism of Action Programmed cell death-1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma; Malignant melanoma; Hodgkin's disease; Liver cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Gastric cancer; Head and neck cancer; Hodgkin's disease; Malignant melanoma; Non-small cell lung cancer; Renal cell carcinoma; Urogenital cancer
  • Registered Liver cancer; Mesothelioma; Small cell lung cancer
  • Phase III Fallopian tube cancer; Glioblastoma; Multiple myeloma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer
  • Phase II/III Non-Hodgkin's lymphoma
  • Phase II Acute myeloid leukaemia; Adrenocortical carcinoma; Biliary cancer; Bladder cancer; Brain metastases; Breast cancer; Cancer; Carcinomatous meningitis; Cervical cancer; Cholangiocarcinoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Genitourinary disorders; Liver metastases; Myelodysplastic syndromes; Pancreatic cancer; Penile cancer; Prostate cancer; Soft tissue sarcoma; Testicular cancer; Thyroid cancer; Uterine cancer; Uveal melanoma
  • Phase I/II Haematological malignancies; Rectal cancer; Sepsis; Solid tumours
  • Phase I Chronic myeloid leukaemia; Glioma; Hepatitis C

Most Recent Events

  • 12 Sep 2018 Bristol-Myers Squibb plans the CheckMate 848 phase II trial for Solid tumours (Combination therapy; Monotherapy; Late-stage disease) in USA, Argentina, Australia, Belgium, Brazil, Canada, Chile, Denmark, France, Germany, Netherlands, Puerto Rico and United Kingdom , (NCT03668119)
  • 12 Sep 2018 Bristol-Myers Squibb plans a phase III trial for Bladder cancer (Combination therapy) in USA, Austria, France and Germany (NCT03661320)
  • 09 Sep 2018 Bristol-Myers Squibb plans a phase I/II trial for Solid tumours (Combination therapy, Metastatic disease, Second-line therapy or greater) in Belgium, Canada and USA in September 2018 (EudraCT2018-002108-15) (NCT03661632)
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