Daratumumab - Janssen Biotech

Drug Profile

Daratumumab - Janssen Biotech

Alternative Names: Anti-CD38-monoclonal-antibody-Genmab; DARZALEX; Humanised anti-CD38 monoclonal antibody; HuMax-CD38; HuMax®-CD38 - Genmab; JNJ-54767414

Latest Information Update: 16 Nov 2018

Price : $50 *
* Final gross price and currency may vary according to local VAT and billing address.
* Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase. A link to download a PDF version of the drug profile will be included in your email receipt. Adis is an information provider. We do not sell or distribute the pharmaceutical compounds written about in this database.

At a glance

  • Originator Genmab
  • Developer Boston Medical Center; Bristol-Myers Squibb; Dana-Farber Cancer Institute; Genentech; Genmab; Janssen Biotech; Janssen Research & Development; M. D. Anderson Cancer Center; Syros Pharmaceuticals
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; CD38 antigen inhibitors; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma; Mantle-cell lymphoma; Follicular lymphoma; Diffuse large B cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple myeloma
  • Phase III Amyloid light-chain amyloidosis
  • Phase II Acute myeloid leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Myelodysplastic syndromes; Precursor B-cell lymphoblastic leukaemia-lymphoma; Precursor T-cell lymphoblastic leukaemia-lymphoma; Prostate cancer; T cell lymphoma; Waldenstrom's macroglobulinaemia
  • Phase I/II Solid tumours
  • Suspended Non-small cell lung cancer
  • No development reported Chronic lymphocytic leukaemia

Most Recent Events

  • 06 Nov 2018 Janssen plans two phase III trials for Cancer
  • 29 Oct 2018 Top-line safety and efficacy data from the phase III MAIA trial in Multiple myeloma released by Genmab
  • 01 Oct 2018 University of California, Celgene, Takeda and Janssen initiates enrolment in a phase II trial for Multiple Myeloma (Combination therapy, Second-line therapy or greater) in USA (NCT03590652)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top