Research programme: antibody therapeutics - Exelixis/Genentech

Drug Profile

Research programme: antibody therapeutics - Exelixis/Genentech

Alternative Names: Anti-DLL4 antibodies; Anti-Notch1-NRR antibodies

Latest Information Update: 10 Mar 2011

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At a glance

  • Originator Exelixis; Genentech
  • Class Monoclonal antibodies
  • Mechanism of Action DLL4 protein inhibitors; Notch signalling pathway inhibitors; Notch-1 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Solid tumours

Most Recent Events

  • 22 Feb 2011 Discontinued - Preclinical for Solid tumours in USA (Parenteral)
  • 26 Oct 2007 Data presented at the 19th AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC-2007) added to the adverse events and Cancer pharmacodynamics sections
  • 06 Jul 2006 This programme is still in active development
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