Bavituximab - Avid Bioservices
Alternative Names: 3G4; Anti-phosphatidylserine monoclonal antibody 3G4; Anti-phospholipid monoclonal antibody 3G4; Anti-PS MAb 3G4; Monoclonal antibody 3G4; TarvacinLatest Information Update: 02 Apr 2024
At a glance
- Originator Avid Bioservices; University of Texas M. D. Anderson Cancer Center
- Developer Avid Bioservices; Feng Biosciences; IMV; Massachusetts General Hospital; Merck Sharp & Dohme; Peregrine Pharmaceuticals; University of Arizona; University of Texas Southwestern Medical Center
- Class Adjuvants; Antineoplastics; Antivirals; Immunotherapies; Monoclonal antibodies
- Mechanism of Action Angiogenesis inhibitors; Antibody-dependent cell cytotoxicity; Phosphatidylserine receptor antagonists
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
- Available For Licensing Yes
Highest Development Phases
- Phase III Non-small cell lung cancer
- Phase II Gastric cancer; Glioblastoma; Liver cancer; Oesophageal cancer
- Suspended Breast cancer; HER2 negative breast cancer; Malignant melanoma; Pancreatic cancer
- No development reported Brain cancer; Hepatitis C; HIV infections; Rectal cancer; Solid tumours; Viral haemorrhagic fevers
- Discontinued Influenza virus infections; Prostate cancer
Most Recent Events
- 22 Aug 2023 Massachusetts General Hospital Cancer Center completes a phase II trial for Glioblastoma (Combination therapy; Newly diagnosed disease) in USA (IV) (NCT03139916)
- 02 Jun 2023 Adverse events and efficacy data from a phase II trial in Gastric cancer and Oesophageal cancer presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
- 20 Jan 2023 Final efficacy and safety data from a phase II trial in liver cancer presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI)