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Navarixin - Ligand Pharmaceuticals/Merck & Co.

Drug Profile

Navarixin - Ligand Pharmaceuticals/Merck & Co.

Alternative Names: MK-7123; PS-291822; SCH 527123; SCH 5271234

Latest Information Update: 03 May 2018

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At a glance

  • Originator Pharmacopeia; Schering-Plough
  • Developer Ligand Pharmaceuticals; Merck & Co
  • Class Anti-inflammatories; Benzamides; Cyclobutanes
  • Mechanism of Action Interleukin 8A receptor antagonists; Interleukin 8B receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Discontinued Asthma; Chronic obstructive pulmonary disease; Psoriasis

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 10 Apr 2018 Phase-II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Israel (PO) (NCT03473925)
  • 22 Mar 2018 Merck & Co. plans a phase II trial of navarixin in combination with pembrolizumab for Solid tumours (Late-stage disease, Combination therapy, Metastatic disease, Second-line therapy or greater) (NCT03473925)
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