Pexastimogene devacirepvec - SillaJen Biotherapeutics

Drug Profile

Pexastimogene devacirepvec - SillaJen Biotherapeutics

Alternative Names: JX-594; Pexa-Vec; TG-6006

Latest Information Update: 26 Sep 2018

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At a glance

  • Originator Jennerex Biotherapeutics
  • Developer GC Pharma; Jennerex; National Cancer Institute (France); National Cancer Institute (USA); Regeneron Pharmaceuticals; SillaJen Biotherapeutics; Transgene; Yonsei University College of Medicine; Yonsei University Health System
  • Class Antineoplastics; Gene therapies; Granulocyte-macrophage colony-stimulating factors; Oncolytic viruses
  • Mechanism of Action Gene transference; Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Liver cancer
  • Phase II Breast cancer; Renal cell carcinoma; Soft tissue sarcoma; Solid tumours
  • Phase I/II Colorectal cancer; Malignant melanoma
  • Preclinical Gastric cancer; Pancreatic cancer
  • No development reported Ovarian cancer

Most Recent Events

  • 04 Sep 2018 Phase-III clinical trials in Liver cancer (First-line therapy, Late-stage disease) in China (Intratumoural) (NCT02562755)
  • 24 Jun 2018 Biomarkers information updated
  • 04 Jun 2018 Efficacy and immunogenicity data from a phase II trial in Cancer released by Transgene
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