Research programme: RNAi therapeutics - Arbutus

Drug Profile

Research programme: RNAi therapeutics - Arbutus

Alternative Names: AB 729; ARB 270729; LNP-siRNA therapeutics - Arbutus; TKM-ALDH; TKM-GSD; TKM-HTG; TKM-Marburg; WEE1/CSN5

Latest Information Update: 16 May 2018

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At a glance

  • Originator Protiva Biotherapeutics
  • Developer Arbutus Biopharma
  • Class Small interfering RNA
  • Mechanism of Action COPS5 protein inhibitors; RNA interference; WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes - Alcoholism; Marburg virus disease; Metabolic disorders

Highest Development Phases

  • Preclinical Hepatitis B
  • Suspended Alcoholism; Hypertriglyceridaemia; Marburg virus disease; Non-alcoholic steatohepatitis; Solid tumours
  • No development reported Lysosomal-storage diseases

Most Recent Events

  • 07 Nov 2018 Arbutus Biopharma plans a clinical trial for AB 729 in Hepatitis B in the second quarter of 2019
  • 07 Nov 2018 Arbutus Biopharma plans clinical combination studies of AB 729 in Hepatitis B in the second quarter of 2019
  • 03 May 2018 Arbutus Biopharma intends to submit IND/CTA-regulatory filing for AB 729 in late-2018 or early-2019 to enable the initiation of a phase I trial in Hepatitis B
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