Research programme: RNAi therapeutics - Arbutus

Drug Profile

Research programme: RNAi therapeutics - Arbutus

Alternative Names: AB 729; LNP-siRNA therapeutics - Arbutus; TKM-ALDH; TKM-GSD; TKM-HTG; TKM-Marburg; WEE1/CSN5

Latest Information Update: 17 Apr 2018

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At a glance

  • Originator Protiva Biotherapeutics
  • Developer Arbutus Biopharma
  • Class Gene therapies; Small interfering RNA
  • Mechanism of Action COPS5 protein inhibitors; RNA interference; WEE1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes - Alcoholism; Marburg virus disease; Metabolic disorders

Highest Development Phases

  • Preclinical Hepatitis B
  • Suspended Alcoholism; Hypertriglyceridaemia; Marburg virus disease; Non-alcoholic steatohepatitis; Solid tumours
  • No development reported Lysosomal-storage diseases

Most Recent Events

  • 12 Apr 2018 Pharmacodynamics data from preclinical studies in Hepatitis B released by Arbutus Biopharma
  • 16 Mar 2018 Arbutus has issued and pending patents for its therapeutic HBV product candidates and LNP delivery technology in countries worldwide
  • 04 Nov 2017 No recent reports of development identified for preclinical development in Lysosomal storage diseases in USA (Parenteral)
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