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Research programme: cancer immunotherapeutics - PsiOxus Therapeutics

Drug Profile

Research programme: cancer immunotherapeutics - PsiOxus Therapeutics

Alternative Names: AbEnAds; anti-human VEGF armed EnAd; anti-PDL1 AbEnAds; NG 345; NG 347; NG 600; NG 641; NG aEpCAM; NG aFAP; NG-600 series

Latest Information Update: 15 May 2019

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At a glance

  • Originator PsiOxus Therapeutics
  • Class Antibodies; Antineoplastics; Bispecific antibodies; Gene therapies; Immunotherapies; Oncolytic viruses
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Cytotoxic T-lymphocyte antigen 4 inhibitors; Epithelial cell adhesion molecule inhibitors; Fibroblast activation protein antagonists; Gene transference; Immunomodulators; Immunostimulants; Programmed cell death-1 ligand-1 inhibitors; Vascular endothelial growth factors modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 14 Aug 2019 PsiOxus Therapeutics plans a phase I trial of of NG 641 for Glandular and epithelial neoplasms (Metastatic disease, Late stage disease, Second line therapy or greater) in October 2019 (NCT04053283)
  • 15 May 2019 US FDA approves IND application for NG 641 in Cancer before May 2019 (PsiOxus pipeline, May 2019)
  • 29 Mar 2019 Pharmacodynamics data from preclinical studies in Cancer presented at the 110th Annual Meeting of the American Association for Cancer Research (AACR-2019)
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