Linagliptin - Boehringer Ingelheim/Eli Lilly

Drug Profile

Linagliptin - Boehringer Ingelheim/Eli Lilly

Alternative Names: BI 1356; BI 1356 BS; Dipeptidyl peptidase IV inhibitor - Boehringer Ingelheim; Ondero; Tradjenta; Trajenta; Trayenta; Trazenta

Latest Information Update: 15 Nov 2018

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At a glance

  • Originator Boehringer Ingelheim
  • Developer Boehringer Ingelheim; Eli Lilly
  • Class Alkynes; Antihyperglycaemics; Piperidines; Purines; Quinazolines; Small molecules
  • Mechanism of Action CD26 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Type 2 diabetes mellitus
  • Phase III Diabetic nephropathies

Most Recent Events

  • 04 Oct 2018 Efficacy and Adverse events data from the phase IV CARMELINA trial in Type-2 diabetes mellitus released by Boehringer Ingelheim and Eli Lilly
  • 30 Sep 2018 Eli Lilly files sNDA for inclusion of data from CARMELINA trial to the label of linagliptin treatment of patients with Type-2 diabetes mellitus in USA
  • 21 Aug 2018 Boehringer Ingelheim completes the phase III CAROLINA trial in Type-2 diabetes mellitus in Argentina, Australia, Belgium, Brazil, Bulgaria, Canada, Chile, Colombia, Czech Republic, Finland, France, Georgia, Germany, Greece, Hong Kong, Hungary, India, Ireland, Israel, Italy, Japan, Malaysia, Mexico, Netherlands, New Zealand, Norway, Peru, Philippines, Portugal, Romania, Russia, Serbia, Slovakia, South Africa, South Korea, Spain, Sweden, Switzerland, Taiwan, Tunisia, Ukraine, United Kingdom and USA (NCT01243424)
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