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Uproleselan - Crescent Biopharma

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Drug Profile

Uproleselan - Crescent Biopharma

Alternative Names: APL-106; GMI-1271; Uproleselan injection - Apollomics/Crescent Biopharma; Uproleselan sodium - Crescent Biopharma

Latest Information Update: 17 Jun 2025

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At a glance

  • Originator GlycoMimetics
  • Developer Apollomics; Crescent Biopharma; National Cancer Institute (USA); University of California, Davis
  • Class Antineoplastics; Antithrombotics; Glycolipids; Small molecules
  • Mechanism of Action E-selectin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute biphenotypic leukaemia; Acute myeloid leukaemia; Chronic myeloid leukaemia; COVID-19 pneumonia; Deep vein thrombosis; Gastrointestinal disorders; Multiple myeloma; Myelodysplastic syndromes; Solid tumours; Stem cell mobilisation

Most Recent Events

  • 16 Jun 2025 GlycoMimetics has merged with Crescent Biopharma to form Crescent Biopharma
  • 21 May 2025 Apollomics terminates its licence for uproleselan in China, Hong Kong, Macau, Taiwan
  • 31 Mar 2025 Discontinued - Phase-I for Acute myeloid leukaemia (Treatment-naive, Combination therapy) in USA (IV)

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