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Uproleselan - GlycoMimetics

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Drug Profile

Uproleselan - GlycoMimetics

Alternative Names: APL-106; GMI-1271; Uproleselan injection - Apollomics/GlycoMimetics; Uproleselan sodium - GlycoMimetics

Latest Information Update: 28 Aug 2024

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At a glance

  • Originator GlycoMimetics
  • Developer Apollomics; GlycoMimetics; National Cancer Institute (USA); University of California, Davis
  • Class Antineoplastics; Antithrombotics; Glycolipids; Small molecules
  • Mechanism of Action E-selectin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Gastrointestinal disorders
  • Phase I/II Acute biphenotypic leukaemia; COVID-19 pneumonia; Deep vein thrombosis; Myelodysplastic syndromes
  • No development reported Chronic myeloid leukaemia; Multiple myeloma; Solid tumours; Stem cell mobilisation

Most Recent Events

  • 28 Aug 2024 No recent reports of development identified for phase-I development in Acute-myeloid-leukaemia(Combination therapy, In the elderly, Treatment-naive, In adults) in USA (IV)
  • 26 Jul 2024 GlycoMimetics terminates a phase I/II trial in Acute myeloid leukaemia (In infants, In children, In adolescent, In adults) in USA (IV, Infusion) (NCT05569512)
  • 04 Jun 2024 Efficacy and adverse events data from a phase III trial in Acute myeloid leukemia released by GlycoMimetics

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