Research programme: dual E-selectin inhibitors/CXCR4 receptor antagonists - Crescent Biopharma
Alternative Names: Anti-Leukemia Drug – Crescent Biopharma; GMI-1257Latest Information Update: 17 Jun 2025
At a glance
- Originator GlycoMimetics
- Developer Crescent Biopharma
- Class Small molecules
- Mechanism of Action CXCR4 receptor antagonists; E-selectin inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Discontinued Acute myeloid leukaemia; Solid tumours
Most Recent Events
- 16 Jun 2025 GlycoMimetics has merged with Crescent Biopharma to form Crescent Biopharma
- 22 Feb 2023 Discontinued - Preclinical for Acute myeloid leukaemia in USA (PO) (GlycoMimetics pipeline, February 2023)
- 22 Feb 2023 Discontinued - Preclinical for Solid tumours in USA (PO) (GlycoMimetics pipeline, February 2023)