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Research programme: prolyl hydroxylase inhibitors - Kyntra Bio

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Drug Profile

Research programme: prolyl hydroxylase inhibitors - Kyntra Bio

Alternative Names: FG 4497; FG 4539; Research programme: HIF prolyl hydroxylase inhibitors - Kyntra Bio

Latest Information Update: 28 Jan 2026

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At a glance

  • Originator FibroGen
  • Developer Kyntra Bio
  • Class Small molecules
  • Mechanism of Action Hypoxia-inducible factor-proline dioxygenase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Cerebral ischaemia; Ischaemia; Kidney disorders; Obesity; Sickle cell anaemia; Stroke; Wounds

Most Recent Events

  • 07 Jan 2026 FibroGen is now called Kyntra Bio
  • 28 Mar 2022 No recent reports of development identified for preclinical development in Cerebral-ischaemia in USA (PO)
  • 28 Mar 2022 No recent reports of development identified for preclinical development in Ischaemia in USA (PO)

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