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TRX 518

Drug Profile

TRX 518

Alternative Names: Anti-GITR monoclonal antibody - Leap Therapeutics; Anti-TNFRSF18 monoclonal antibody; TRX518

Latest Information Update: 21 Dec 2018

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At a glance

  • Originator Tolerx
  • Developer GITR Inc; Leap Therapeutics
  • Class Antineoplastics; Antivirals; Monoclonal antibodies
  • Mechanism of Action TNFRSF18 protein stimulants; Tumour necrosis factor receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • No development reported Malignant melanoma; Viral infections

Most Recent Events

  • 14 Dec 2018 Updated efficacy data from a phase I trial in Solid tumours presented at the ESMO Immuno-Oncology Congress (ESMO-2018)
  • 08 Aug 2018 Updated efficacy data from a phase I trial in Solid tumours released by Leap Therapeutics
  • 23 Jul 2018 Leap Therapeutics collaborates with Merck KGaA and Pfizer for a phase I/II trial in Solid tumours
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