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Losmapimod - Fulcrum Therapeutics/GlaxoSmithKline

Drug Profile

Losmapimod - Fulcrum Therapeutics/GlaxoSmithKline

Alternative Names: 856553; FTX-1821; GS856553; GSK 856553; GW 856553; GW856553X

Latest Information Update: 21 Nov 2019

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At a glance

  • Originator GlaxoSmithKline
  • Developer Fulcrum Therapeutics; GlaxoSmithKline
  • Class Anti-inflammatories; Antiasthmatics; Antirheumatics; Cardiovascular therapies; Small molecules
  • Mechanism of Action DUX4 protein inhibitors; P38 mitogen-activated protein kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute coronary syndromes
  • Phase II Chronic obstructive pulmonary disease; Facioscapulohumeral muscular dystrophy; Focal segmental glomerulosclerosis
  • No development reported Inflammation
  • Discontinued Atherosclerosis; Dyslipidaemias; Major depressive disorder; Neuropathic pain; Rheumatoid arthritis

Most Recent Events

  • 04 Oct 2019 Preliminary pharmacokinetics and adverse events data from a phase-I trial in Facioscapulohumeral muscular dystrophy released by Fulcrum Therapeutics
  • 26 Aug 2019 Fulcrum Therapeutics initiates a phase-I trial for Facioscapulohumeral muscular dystrophy and healthy volunteers before August 2019 (PO)
  • 26 Aug 2019 Phase-II clinical trials in Facioscapulohumeral muscular dystrophy in Netherlands (PO) (NCT04004000)
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