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Rexlemestrocel-L - Mesoblast/Teva Pharmaceutical Industries

Drug Profile

Rexlemestrocel-L - Mesoblast/Teva Pharmaceutical Industries

Alternative Names: Allogeneic mesenchymal precursor cells - Mesoblast; Allogeneic STRO-3 immunoselected bone marrow-derived mesenchymal precursor cells (MPCs) - Mesoblast; CEP-41750; Mesenchymal stem cell therapy - Mesoblast; MPC 06; MPC-06-ID; MPC-150; MPC-150-IM; MPC-25; MPC-25-IC; MPC-25-Osteo; MPC-300; MPC-300-IV; MPC-75-IA; MPC-CBE; MPC-MICRO-IO; MSB-CAR001; NeoFuse; Replicart; Revascor

Latest Information Update: 02 Jun 2020

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At a glance

  • Originator Hanson Institute; Institute of Medical and Veterinary Science
  • Developer Angioblast Systems; Mesoblast; Teva Pharmaceutical Industries
  • Class Anti-inflammatories; Antihypercalcaemics; Antineoplastics; Antirheumatics; Heart failure therapies; Skin disorder therapies; Stem cell therapies
  • Mechanism of Action Cell replacements; Osteogenesis stimulants; Tissue replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Heart failure; Haematological malignancies
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Heart failure; Hodgkin's disease; Intervertebral disc degeneration; Non-Hodgkin's lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase II Myocardial infarction; Osteoarthritis; Rheumatoid arthritis; Spondylosis; Type 2 diabetes mellitus
  • Phase I/II Diabetic nephropathies
  • No development reported Age-related macular degeneration; Fracture; Lung disorders; Peripheral arterial disorders; Skin ulcer

Most Recent Events

  • 02 Jun 2020 Mesoblast in collaboration with Grunenthal plans a confirmatory phase III trial in Chronic low back pain in Europe
  • 26 Nov 2019 Meoblast and the International Center for Health Outcomes Innovation Research (InCHOIR) at the Icahn School of Medicine at Mount Sinai in New York agrees on the protocol in line with the US FDA guidance for a phase III trial in Heart failure
  • 26 Nov 2019 Mesoblast and Center for Health Outcomes Innovation Research (InCHOIR) at the Icahn School of Medicine at Mount Sinai in New York plans a confirmatory phase III trial for Heart failure in the US
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