Domatinostat - 4SC

Drug Profile

Domatinostat - 4SC

Alternative Names: 4SC-202

Latest Information Update: 17 Aug 2018

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At a glance

  • Originator Nycomed
  • Developer 4SC
  • Class Antineoplastics; Benzamides; Pyrazoles; Pyrroles; Small molecules; Sulfones
  • Mechanism of Action BRD4 protein modulators; HDAC1 protein inhibitors; HDAC2 protein inhibitors; HDAC3 protein inhibitors; Lysine specific demethylase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Malignant melanoma
  • Preclinical Pancreatic cancer; Small cell lung cancer
  • No development reported Cancer; Haematological malignancies

Most Recent Events

  • 15 Aug 2018 US FDA approves IND application for domatinostat in Melanoma
  • 15 Aug 2018 4SC plans to initiate recruitment in the phase Ib/II SENSITIZE study in USA in 2019
  • 03 Jul 2018 4SC plans a pivotal clinical trial in Malignant melanoma (Cutaneous melanoma) in 2019
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