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IRX 2

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Drug Profile

IRX 2

Alternative Names: Citoplurikin; IRX-2

Latest Information Update: 28 Jun 2025

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At a glance

  • Originator IRX Therapeutics
  • Developer City of Hope National Medical Center; Ernexa Therapeutics; Eterna Therapeutics; H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (USA); University of Southern California
  • Class Antineoplastics; Cytokines
  • Mechanism of Action Dendritic cell stimulants; Natural killer cell stimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Squamous cell cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cervical intraepithelial neoplasia; Squamous cell cancer; Triple negative breast cancer; Vulvar intraepithelial neoplasia
  • No development reported Liver cancer; Solid tumours

Most Recent Events

  • 28 Jun 2025 No recent reports of development identified for phase-I development in Squamous-cell-cancer(Combination therapy, Metastatic disease, Recurrent, Second-line therapy or greater) in USA (Parenteral, Injection)
  • 13 Apr 2025 University of Southern California in collaboration withIRX Therapeutics terminates a phase-II clinical trials in Vulvar intraepithelial neoplasia and Cervical intraepithelial neoplasia (Combination therapy) in USA (SC) due to lack of efficacy (NCT03267680)
  • 25 Mar 2025 Eterna Therapeutics is now called Ernexa Therapeutics

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