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IMNN 001

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Drug Profile

IMNN 001

Alternative Names: DNA-based immunotherapy - Imunon; EGEN-001; GEN-1; IL-12 gene therapy - EGEN; IL-12 gene therapy - Expression Genetics; IL-12 gene therapy - Imunon; IMNN-001; Interleukin-12 gene therapy - EGEN; Interleukin-12 gene therapy - Expression Genetics; Interleukin-12 gene therapy - Imunon; phIL-12-005/PPC

Latest Information Update: 26 Nov 2025

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At a glance

  • Originator Expression Genetics
  • Developer Gynecologic Oncology Group; Imunon
  • Class Antineoplastics; Cytokine genes; Gene therapies; Immunotherapies
  • Mechanism of Action Interleukin 12 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • No development reported Colorectal cancer
  • Discontinued Glioblastoma

Most Recent Events

  • 13 Nov 2025 Efficacy and adverse events data from a phase III OVATION 3 trial in Ovarian cancer presented at Imunon R and D day (10 November 2025)
  • 13 Nov 2025 Pharmacodynamics and adverse events data from a phase I/II MRD trial in Ovarian cancer released by Imunon R and D day (10 November 2025)
  • 13 Nov 2025 Pharmacodynamics data from a phase I/II OVATION 2 trial in Ovarian cancer released by Imunon

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