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GEN 1

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Drug Profile

GEN 1

Alternative Names: EGEN-001; GEN-1; IL-12 gene therapy - Celsion Corporation; IL-12 gene therapy - EGEN; IL-12 gene therapy - Expression Genetics; Interleukin-12 gene therapy - Celsion Corporation; Interleukin-12 gene therapy - EGEN; Interleukin-12 gene therapy - Expression Genetics; phIL-12-005/PPC

Latest Information Update: 31 Oct 2018

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At a glance

  • Originator Expression Genetics
  • Developer Celsion Corporation; Gynecologic Oncology Group
  • Class Antineoplastics; Cytokine genes; Gene therapies; Immunotherapies; Interleukins
  • Mechanism of Action Gene transference; Immunomodulators; Interleukin 12 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Preclinical Glioblastoma
  • No development reported Colorectal cancer

Most Recent Events

  • 24 Oct 2018 Updated efficacy data from the phase Ib OVATION I trial in Ovarian cancer released by Celsion Corporation
  • 30 Jun 2018 Phase-I/II clinical trials in Fallopian tube cancer (Late-stage disease, Newly diagnosed, Neoadjuvant therapy, Metastatic disease) in USA (Intraperitoneal) (NCT03393884)
  • 30 Jun 2018 Phase-I/II clinical trials in Ovarian cancer (Late-stage disease, Newly diagnosed, Metastatic disease, Neoadjuvant therapy) in USA (Intraperitoneal) (NCT03393884)
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