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IMNN 001

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Drug Profile

IMNN 001

Alternative Names: DNA-based immunotherapy - Imunon; EGEN-001; GEN-1; IL-12 gene therapy - EGEN; IL-12 gene therapy - Expression Genetics; IL-12 gene therapy - Imunon; IMNN-001; Interleukin-12 gene therapy - EGEN; Interleukin-12 gene therapy - Expression Genetics; Interleukin-12 gene therapy - Imunon; phIL-12-005/PPC

Latest Information Update: 12 Jun 2025

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At a glance

  • Originator Expression Genetics
  • Developer Gynecologic Oncology Group; Imunon
  • Class Antineoplastics; Cytokine genes; Gene therapies; Immunotherapies
  • Mechanism of Action Gene transference; Immunomodulators; Interferon-gamma expression stimulants; Interleukin 12 replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity No

Highest Development Phases

  • Phase III Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • No development reported Colorectal cancer
  • Discontinued Glioblastoma

Most Recent Events

  • 03 Jun 2025 Efficacy data from a phase I/II OVATION 2 trial in Ovarian cancer released by Imunon
  • 23 May 2025 Updated efficacy and adverse event data from a phase I/II OVATION 2 trial in Ovarian cancer released by Imunon
  • 08 May 2025 Phase-III clinical trials in Fallopian tube cancer (Combination therapy, Newly diagnosed, Late-stage disease, First-line therapy) in USA (Intraperitoneal) (NCT06915025)

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