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Research programme: eye disorder therapeutics - Aerie Pharmaceuticals

Drug Profile

Research programme: eye disorder therapeutics - Aerie Pharmaceuticals

Alternative Names: AR 13154; AR-101; AR-13165; AR-13533; AR-202

Latest Information Update: 29 Apr 2019

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At a glance

  • Originator Duke University Medical Center
  • Developer Aerie Pharmaceuticals; Ramot at Tel Aviv University
  • Class Eye disorder therapies; Small molecules
  • Mechanism of Action Amyloid beta-protein inhibitors; Janus kinase inhibitors; Norepinephrine plasma membrane transport protein inhibitors; Platelet-derived growth factor beta receptor antagonists; Protein kinase C inhibitors; Rho-associated kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Diabetic retinopathy; Dry age-related macular degeneration; Neurological disorders
  • No development reported Glaucoma

Most Recent Events

  • 31 Mar 2019 Aerie Pharmaceuticals files an IND application with the US FDA for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME)
  • 11 Feb 2019 Aerie Pharmaceuticals plans a phase I/II trial of AR 13503 for Neovascular age-related macular degeneration and Diabetic macular oedema in June 2019 (Intravitreal, Implant) (NCT03835884)
  • 01 Aug 2018 Aerie Pharmaceuticals announces intention to submit IND application to the US FDA for AR 13503 in Wet age-related macular degeneration and Diabetic retinopathy in March 2019
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