Tanespimycin

Drug Profile

Tanespimycin

Alternative Names: 17-AAG; 17-allylamino-17-demethoxy-geldanamycin; KOS-953

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator National Institutes of Health (USA)
  • Developer Kosan Biosciences
  • Class Antineoplastics; Benzoquinones; Cytostatic antibiotics; Macrocyclic lactams; Small molecules
  • Mechanism of Action HSP90 heat-shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Malignant melanoma; Multiple myeloma

Most Recent Events

  • 05 Dec 2009 Efficacy, adverse events and pharmacodynamics data from a phase II/III trial in Multiple myeloma presented at the 51st Annual Meeting and Exposition of the American Society of Hematology (ASH-2009)
  • 04 Dec 2009 No development reported - Phase-II for Malignant melanoma in Australia (IV)
  • 04 Dec 2009 No development reported - Phase-II for Malignant melanoma in USA (IV)
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