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Drug Profile


Alternative Names: Diazo-oxo-L-norleucine/PEG-glutaminase; Diazooxonorleucine/PEG-glutaminase; DON/PEG-PGA; GlutaDON; PEG-glutaminase/diazooxonorleucine; PEG-PGA/DON

Latest Information Update: 16 Jun 2015

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At a glance

  • Originator New Medical Enzymes AG
  • Class Antineoplastics; Azo compounds; Glutaminase; Norleucines
  • Mechanism of Action DNA synthesis inhibitors; Glutamine inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Colorectal cancer
  • Phase I/II Gastric cancer; Non-small cell lung cancer; Renal cell carcinoma; Solid tumours

Most Recent Events

  • 16 Jun 2015 Phase-I/II development is ongoing for metastatic colorectal cancer, renal cell carcinoma, non-small cell lung cancer, gastric cancer and other solid tumours in Europe
  • 26 Feb 2013 New Medical Enzymes terminates a phase II trial in Colorectal cancer (metastatic) in Poland (EudraCT2009-017871-13)
  • 01 Feb 2013 Phase-I/II clinical trials in Gastric cancer in Germany (IV)
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