Drug Profile

Rivoceranib - HLB

Alternative Names: Aitan; Apatinib; Apatinib mesylate; Apatinib Mesylate Tablets; YN-968-D1

Latest Information Update: 21 Jul 2025

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At a glance

Originator Advenchen Laboratories LLC
Developer Elevar Therapeutics; Henan Cancer Hospital; HLB LifeScience; Hunan Cancer Hospital; Jiangsu Hengrui Medicine Co.; Peking University
Class Amides; Antineoplastics; Cyclopentanes; Nitriles; Pyridines; Small molecules
Mechanism of Action Vascular endothelial growth factor receptor-2 antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Liver cancer; Gastric cancer; Adenoid cystic carcinoma
New Molecular Entity Yes

Marketed Gastric cancer; Liver cancer
Phase III Fallopian tube cancer; Non-small cell lung cancer; Ovarian cancer; Peritoneal cancer
Phase II Adenoid cystic carcinoma; Breast cancer; Cholangiocarcinoma; Colorectal cancer; Lung cancer; Malignant melanoma; Osteosarcoma; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Triple negative breast cancer; Uterine cancer
No development reported Oesophageal cancer

04 Jul 2025 Jiangsu HengRui Medicine Co terminates a phase II trial in Non-small cell lung cancer (Late-stage disease, Metastatic disease, Combination therapy, First-line therapy) in China (PO) due to the sponsor's R&D strategy is adjusted (NCT03777124)
25 Apr 2025 Adverse events and efficacy data from a phase-II trial in Adenoid cystic carcinoma presented at the 116^th Annual Meeting of the American Association for Cancer Research (AACR-2025)
21 Oct 2024 FDA assigns PDUFA action date of (20/03/2025) for rivoceranib for Liver cancer (Combination therapy, First-line therapy, Late-stage disease)

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